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Monoclonal Anti-CD123 PE produced in mouse，100YL4，SAB4702003-100TST，Sigma

销售价： ¥ 2145.34 / 件

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订货号： 0BQ1239

品牌型号： Sigma SAB4702003-100TST

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最小订货量： 1件

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商品介绍
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产品介绍 Product Description

General description

CD123 is the alpha chain of interleukin 3 receptor (IL-3R alpha). This subunit heterodimerizes with the interleukin 3 receptor beta chain (CD131), which is shared with other receptors. CD123 interacts with IL-3 specifically, but with low affinity, and association with the beta subunit confers high affinity binding to the receptor heterodimer. Both chains are required for signaling, but receptor activation and signal transduction depend on IL-3 binding to CD123 as the initial step.

Immunogen

IL3 receptor alpha chain expressed on the surface of transiently transfected COS cells

Biochem/physiol Actions

The mouse monoclonal antibody 6H6 recognizes an extracellular epitope of CD123 (interleukin 3 receptor alpha), a 60-70 kDa transmembrane protein expressed by myeloid precursors, megakaryocytes, macrophages, dendritic cells, mast cells, basophils, and some B cells. This antibody does not inhibit IL-3 binding to its receptor.

Physical form

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preparation Note

Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Other Notes

The antibody solution should be gently mixed before use.

技术参数 Specifications

conjugate	phycoerythrin (R-PE) conjugate
Quality Segment	100
antibody product type	primary antibodies
clone	6H6, monoclonal
form	buffered aqueous solution
species reactivity	human
technique(s)	flow cytometry: suitable
isotype	IgG1
UniProt accession no.	P26951
storage temp.	2-8°C
target post-translational modification	unmodified
Gene Information	human ... IL3RA(3563)

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