PF-670462，25MG，SML0795-25MG，Sigma

Biochem/physiol Actions

PF-670462 is also termed as 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine dihydrochloride). It participates in ceramide transfer between Golgi and ER (endoplasmic reticulum) compartments. PF-670462 affects actin filament consolidation. It also hinders the stability at the front edge of cells treated with N-formyl Met-Leu-Phe.
PF-670462 is a selective inhibitor of the δ- and ε-isoforms of casein kinase I, with IC₅₀ values of 7.7 and 14 nM respectively, and >30 selectivity relative to 42 other kinases tested. Casein kinase Iε phosphorylates PER proteins, which are involved in setting the period of the circadian pacemaker or clock. PF-670462 is potent (IC₅₀ 7.7 nM) and effective in vivo (i.e. it induces profound phase delays in circadian periodicity).
PF-670462 is a selective inhibitor of the δ- and ε-isoforms of casein kinase I.