7-乙基-10-羟基喜树脂，10MG，H0165-10MG，Sigma

Application

7-Ethyl-10-hydroxycamptothecin has been used:

• to inhibit enterovirus 71 (EV71) (H) infection
• to screen the chemosensitivity of pancreatic adenocarcinoma cells
• as a chemical to study its ability to reverse multidrug resistance (MDR), due to ATP binding cassette (ABC) transporters

Biochem/physiol Actions

Active metabolite of irinotecan. Inhibitor of topoisomerase I.
Active metabolite of irinotecan. Inhibitor of topoisomerase I.. Gene expression analysis of colon cancer cell lines treated with SN-38 showed differential effects: the majority of affected genes were down-regulated (including, most strongly, genes related to receptor and kinase activity, signal transduction, apoptosis, RNA processing, protein metabolism and transport, cell cycle and transcription. Some of the up-regulated genes were involved in apoptosis, transcription, development and differentiation.