非诺多泮 甲磺酸酯,10MG,SML0198-10MG,Sigma

销售价: ¥ 1342.28 / 件
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订货号 0BP6342
品牌型号 Sigma SML0198-10MG
货期 询货期
最小订货量 1件
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产品介绍 Product Description

Application

Fenoldopam mesylate may be used to study dopamine D1-mediated cell signaling.


Biochem/physiol Actions

Fenoldopam mesylate (FM) is considered as an effective therapeutic agent to prevent the onset of postoperative AKI (PO-AKI). In healthy cats, FM can stimulate diuresis and be well-tolerated. This benzazepine-derivative is regional specific and does not cause cerebral vasodilation.
Dopamine D1-receptor agonist; Antihypertensive
Fenoldopam mesylate is a selective dopamine D1 receptor agonist used as an antihypertensive agent. It is an agonist for D1-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors. It has no significant affinity for D2-like receptors, α1 and α-adrenoceptors, 5HT1 and 5HT2 receptors, or muscarinic receptors. Fenoldopam mesylate causes peripheral vasodilation by stimulating dopamine-1receptors and α2-adrenoceptors, increasing renal blood flow.


Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.


技术参数 Specifications
Quality Segment100
assay≥98% (HPLC)
formpowder
storage conditiondesiccated
color white to tan
mp271 °C (lit.)
solubilityDMSO: ≥15 mg/mL at ~60 °C
storage temp.room temp
SMILES stringCS(O)(=O)=O.Oc1ccc(cc1)C2CNCCc3c(Cl)c(O)c(O)cc23
InChI1S/C16H16ClNO3.CH4O3S/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21;1-5(2,3)4/h1-4,7,13,18-21H,5-6,8H2;1H3,(H,2,3,4)
InChI keyCVKUMNRCIJMVAR-UHFFFAOYSA-N
Gene Informationhuman ... DRD1(1812)
长度(mm)
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