- 商品介绍
- 规格参数
- 包装参数
General description
Transferrin receptor (TFRC), also known as p90, CD71, TFR and TFR1, is a transmembrane glycoprotein. It is composed of two disulphide-bonded sub-units, contains three N-linked glycan units and is post-translationally modified with phosphate and fatty acyl groups.
Immunogen
synthetic peptide corresponding to an internal sequence of human TFRC, conjugated to KLH
Application
Anti-TFRC antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
Biochem/physiol Actions
Transferrin receptor (TFRC) mediates cellular iron uptake. It binds iron bound transferrin on the cell surface, and the receptor ligand complex undergoes endocytosis via clathrin coated pits. Endosomal acidification leads to iron release, which is transported to the cytosol or to the mitochondria in erythroid cells. The apotransferrin receptor complex is then recycled to the cell surface, where the affinity of apotransferrin for TFRC drops, resulting in its dissociation. TFRC is necessary for development of erythrocytes and the nervous system.
Physical form
solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 200 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen ~90 kDa |
| species reactivity | mouse, rat, human |
| concentration | ~1.0 mg/mL |
| technique(s) | indirect immunofluorescence: 10-20 μg/mL using rat NRK cells,western blot: 2.5-5.0 μg/mL using whole extracts of human U-2-OS and mouse Neuro-2a cells |
| UniProt accession no. | P02786 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... TFRC(7037) mouse ... Tfrc(22042) rat ... Tfrc(64678) |
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