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- 规格参数
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General description
FOLR2 (folate receptor beta) is a cell surface protein that was originally thought to be specific for placenta, but it can be also expressed in other tissues, including hematopoietic cells. Its expression is increased in malignant tissues. FOLR2 may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. FOLR2 is a marker for macrophages generated in the presence of M-CSF (M2), including M2-like tumor-associated macrophages, which exert potent immunosuppressive functions within the tumor environment, but not GM-CSF (M1), and whose expression correlates with increased folate uptake ability.
Immunogen
BW5147alpha,beta- cells
Biochem/physiol Actions
The mouse monoclonal antibody EM-35 recognizes an extracellular epitope on FOLR2, a 30-40 kDa cell surface protein serving as a receptor for folic acid.
Physical form
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Preparation Note
Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Other Notes
The antibody solution should be gently mixed before use.
| conjugate | phycoerythrin (R-PE) conjugate |
| Quality Segment | 100 |
| antibody product type | primary antibodies |
| clone | EM-35, monoclonal |
| form | buffered aqueous solution |
| species reactivity | human |
| concentration | 0.1 mg/ml |
| technique(s) | flow cytometry: suitable |
| isotype | IgG1 |
| UniProt accession no. | P14207 |
| storage temp. | 2-8°C |
| target post-translational modification | unmodified |
| Gene Information | human ... FOLR2(2350) |
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¥ 1866.29
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¥ 1568.60
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¥ 1749.15
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¥ 4011.97
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¥ 1783.21
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¥ 1586.69
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