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Biochem/physiol Actions
BF-170 is a new probe for neurofibrillary tangles (tau fibrils) with greater binding affinity to tau than to Aβ fibrils.
BF-170 is a new probe for neurofibrillary tangles (tau fibrils). It exhibits greater binding affinity to tau than to Aβ fibrils, EC50 = 221 nM vs. EC50 = 786 nM (Ki for Aβ > 5,000 nM). BF-170 demonstrates fast clearance from the brain; clearly visualizes neurofibrillary tangles, neuropil threads, and paired helical filament-type neuritis. BF-70 may become one of the candidate compounds for in vivo imaging of tau pathology associated with Alzheimer′s disease and is a useful tool in distinguishing among tau and Aβ fibrils specifically in AD.
Disclaimer
Product is air sensitive, store under inert gas.
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | solid |
| storage condition | desiccated,protect from light,under inert gas |
| color | orange |
| solubility | H2O: 10 mg/mL |
| storage temp. | −20°C |
| SMILES string | Cl[H].Nc1ccc(cc1)-c2ccc3ccccc3n2 |
| InChI | 1S/C15H12N2.ClH/c16-13-8-5-12(6-9-13)15-10-7-11-3-1-2-4-14(11)17-15;/h1-10H,16H2;1H |
| InChI key | UYYPMQOFLJHJAW-UHFFFAOYSA-N |
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¥ 4039.86
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¥ 6894.69
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¥ 3812.28
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¥ 2268.97
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¥ 1749.15
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¥ 5061.38
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