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General description
Chemical structure: peptide
Biochem/physiol Actions
Exhibits co-existent antimicrobial and antiproteolytic activities.1 Inhibits WAP-type four-disulfide core (WFDC) domain containing elastases. Antimicrobial spectrum: Gram-positive and Gram-negative bacteria.
Inhibitor of human leukocyte elastase and proteinase 3, originally isolated from the skin of patients with psoriasis. May protect against certain autoimmune tissue damage.
Inhibitor of human leukocyte elastase and proteinase 3, originally isolated from the skin of patients with psoriasis. May protect against certain autoimmune tissue damage. An elastase inhibitor which is an active fragment of elafin, as well as elafin itself, can also be found in bronchial carcinoma secretions.
| recombinant | expressed in Saccharomyces cerevisiae |
| Quality Level | 200 |
| assay | >90% (by MS, HPLC and SDS-PAGE) |
| form | powder |
| potency | 1.7 x 10-10 M Ki (human leukocyte elastase),4.2 x 10-10 M Ki (human proteinase 3) |
| mol wt | ~6 kDa |
| UniProt accession no. | P19957 |
| antibiotic activity spectrum | Gram-negative bacteria,Gram-positive bacteria |
| mode of action | enzyme | inhibits |
| shipped in | ambient |
| storage temp. | −20°C |
| Gene Information | human ... PI3(5266) |
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¥ 638.71
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¥ 1316.02
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