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Biochem/physiol Actions
Isoforskolin is a naturally occurring diterpene with anti-inflammatory activity. It has been shown to downregulate the expression of proinflammatory compounds. In an experimental mouse model of Lyme Disease induced arthritis isoforskolin downregulated the transcription and expression of TNF-α and IL-6 induced by recombinant Borrelia burgdorferi basic membrane protein A (rBmpA). In a rat asthmatic model isoforskolin down-regulated production of transforming growth factor β1 (TGF-β1) and interleukin-1β (IL-1β) which was accompanied by inhibition of inflammation and airway remodeling.
| Quality Level | 100 |
| assay | ≥95% (HPLC) |
| form | powder |
| optical activity | [α]/D -8 to -5°, c = 0.5 in chloroform-d |
| color | white to beige |
| solubility | DMF:H2O (9:1): 2 mg/mL, clear |
| storage temp. | −20°C |
| SMILES string | CC(=O)O[C@@H]1[C@H](O)[C@@]2(C)O[C@](C)(CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)C13)C=C |
| InChI | 1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(28-12(2)23)17(26)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16?,17-,19-,20-,21+,22-/m0/s1 |
| InChI key | CLOQVZCSBYBUPB-VDCUXWMXSA-N |
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¥ 673.51
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¥ 625.35
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¥ 711.69
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¥ 580.62
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¥ 3317.36
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¥ 2290.18
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¥ 1316.02
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¥ 1029.59
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