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Biochem/physiol Actions
Cyclovirobuxine D is a steroidal alkaloid component extracted from the root of medical plant Buxus microphylla that exhibits beneficial effect on heart failure, arrhythmias, myocardial ischemia and other cardiovascular diseases. Apparently it increases the release and uptake of Ca(2+) in systolic and diastolic periods. Cyclovirobuxine D induces mitochondria-mediated apoptosis in numerous cancer cells including breast and gastric cancer cells. It induces autophagy-associated cell death via the Akt/mTOR pathway in human breast cancer cells.
Steroidal alkaloid component extracted from the root of medical plant Buxus microphylla that exhibits beneficial effect on cardiovascular diseases
| Quality Level | 100 |
| assay | ≥90% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | 0.1 M HCl: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
| SMILES string | C[C@H](NC)[C@@]1([H])[C@H](O)C[C@@]2(C)[C@]3([H])CC[C@@]4([H])C(C)(C)[C@@H](NC)CC[C@]4(C5)[C@]35CC[C@@]21C |
| InChI | 1S/C26H46N2O/c1-16(27-6)21-17(29)14-24(5)19-9-8-18-22(2,3)20(28-7)10-11-25(18)15-26(19,25)13-12-23(21,24)4/h16-21,27-29H,8-15H2,1-7H3/t16-,17+,18-,19-,20-,21-,23+,24-,25+,26-/m0/s1 |
| InChI key | GMNAPBAUIVITMI-ABNIRSKTSA-N |
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