Anti-phospho-GSK3A/GSK3B (Y216 + Y279) antibody, clone 4A5, Rabbit Monoclonal，1004G，SAB6010071-100UL，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.

Immunogen

A synthesized peptide derived from human Phospho-GSK3A/GSK3B (Y216 + Y279)

Physical form

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Preparation Note

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Other Notes

VS-pY-IS

技术参数 Specifications

recombinant	expressed in HEK 293 F cells
Quality Level	100
conjugate	unconjugated
antibody product type	primary antibodies
clone	4A5, recombinant monoclonal
form	liquid
mol wt	150 kDa
purified by	affinity chromatography
species reactivity	human
concentration	0.6mg/ml
technique(s)	ELISA: 2000:10000,flow cytometry: 1:50-1:200,immunofluorescence: 1:50-1:200,immunohistochemistry: 1:50-1:200
isotype	IgG
UniProt accession no.	P49840
shipped in	wet ice
storage temp.	-10 to -25°C
target post-translational modification	phosphorylation (pTyr216 + pTyr279)

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