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Biochem/physiol Actions
Potent and selective toll-like receptor 8 (TLR8) agonist that augments the lytic function of NK cells and enhances antibody-dependent cellular cytotoxicity.
Motolimod (VTX-2337) is a potent and selective human toll-like receptor 8 (TLR8) agonist (EC50 = 100 nM; no murine TLR8-stimulating potenty) with greatly reduced TLR7 potency (EC50 >30 µM) and little activity toward TLR3/4/5/8. Motolimod induces proinflammatory mediators production in huaman PBMCs (TNFα/IL12 EC50 = 140/120 nM) by stimulating TLR8-expressing monocytes and mDCs, but not non-TLR8-expressing pDCs. Motolimod augments the lytic function of NK cells and enhances antibody-dependent cellular cytotoxicity (ADCC).
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear (Warmed) |
| storage temp. | 2-8°C |
| SMILES string | N4(CCCC4)C(=O)c1ccc(cc1)c2cc3c(cc2)C=C(C=C(N3)N)C(=O)N(CCC)CCC |
| InChI | 1S/C28H34N4O2/c1-3-13-31(14-4-2)28(34)24-17-23-12-11-22(18-25(23)30-26(29)19-24)20-7-9-21(10-8-20)27(33)32-15-5-6-16-32/h7-12,17-19,30H,3-6,13-16,29H2,1-2H3 |
| InChI key | CQAGPRVMJDWWEA-UHFFFAOYSA-N |
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