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Biochem/physiol Actions
FIT-039 is a potent and selective cyclin-dependent kinase 9 (CDK9) inhibitor that binds to the ATP -binding pocket of CDK9 and inhibits the kinase activity of P-TEFb complex. FIT-039 inhibits replication of herpes simplex virus 1 (HSV-1), HSV-2, human adenovirus, and human cytomegalovirus in cultured cells. FIT-039 ointment inhibits formation of skin legion in a mice HSV-1 infection model.
potent and selective cyclin-dependent kinase 9 (CDK9) inhibitor; antiviral agent
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | Fc1cc(c(cc1)N3CCCCC3)NC(=S)c2ccncc2 |
| InChI key | VRKZHYSJZOUICG-UHFFFAOYSA-N |
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¥ 2019.57
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¥ 1866.29
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¥ 1451.54
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¥ 238.17
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¥ 2268.97
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¥ 2617.87
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¥ 2099.27
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¥ 165230.53
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¥ 390328.90
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