Monoclonal Anti-MBNL1 antibody produced in mouse，100UL，M3320-100UL，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

Muscle blind-like 1 (MBNL1) is a homolog of human muscle blind like proteins. Proteins of the MBNL (muscleblind-like) family are mainly expressed in skeletal muscle neuronal tissues, thymus, liver and kidney.

Immunogen

recombinant muscleblind-like1 (MBNL1) fusion protein.

Application

Monoclonal Anti-MBNL1 antibody produced in mouse has been used in: immunoblotting, immunohistochemistry and immunocytochemistry

Biochem/physiol Actions

Proteins of the MBNL (muscleblind-like) family enhance inclusion or exclusion of specific exons on different pre-mRNAs by inhibiting the activity of CUG-BP and ETR-3-like factors (CELF proteins) bound to distinct intronic sites. MBNL1 may be implicated in the stimulation of muscle differentiation. Mice knockouts for the MBNL1 gene develop muscle, eye, and RNA splicing abnormalities that are characteristic of the neuromuscular disease myotonic dystrophy (DM) disease.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

技术参数 Specifications

biological source	mouse
Quality Level	200
conjugate	unconjugated
antibody form	purified immunoglobulin
antibody product type	primary antibodies
clone	HL 1822 (3A4-1E9), monoclonal
form	buffered aqueous solution
mol wt	antigen ~42 kDa
species reactivity	monkey, mouse, human
concentration	~1 mg/mL
technique(s)	immunocytochemistry: suitable,immunohistochemistry: suitable,microarray: suitable,western blot: 0.2-0.5 μg/mL using HeLa nuclear cell extract
isotype	IgG1
UniProt accession no.	Q9NR56
shipped in	dry ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... MBNL1(4154) mouse ... Mbnl1(56758)

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