Tafamidis meglumine,50MG,SML4132-50MG,Sigma

销售价: ¥ 3833.03 / 件
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订货号 0BN4111
品牌型号 Sigma SML4132-50MG
货期 询货期
最小订货量 1件
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产品介绍 Product Description

Biochem/physiol Actions

Transthyretin (TTR) tetramer stabilizer.
Tafamidis is a transthyretin (TTR) tetramer stabilizer that binds selectively and with negative cooperativity to the two normally unoccupied thyroxine-binding sites of the tetramer (Kd ~2 nM and ~200 nM), kinetically stabilizing the wild-type as well as the variant TTR complexes (V30M, F64S, Y69H, I84S, V122I, and L111M) and preventing their dissociation into fibril-forming monomers.


Disclaimer

Hygroscopic


技术参数 Specifications
Quality Level100
assay≥98% (HPLC)
formpowder
storage conditiondesiccated
color white to pink
solubilityDMSO: 2 mg/mL, clear (Warmed)
storage temp.2-8°C
SMILES stringOC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNC.ClC1=CC(Cl)=CC(C(OC2=C3)=NC2=CC=C3C(O)=O)=C1
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