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产品介绍
Product Description
Biochem/physiol Actions
BRD4770 is a selective inhibitor of the histone methyltransferase G9a.
BRD4770 is a selective inhibitor of the histone methyltransferase G9a. BRD4770 blocks lysine residue 9 methylation of histone H3 without inducing apoptosis. In PANC-1 cells, BRD4770 activates the ataxia telangiectasia mutated (ATM) pathway, induces senescence and inhibits anchorage-dependent and -independent growth.
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 5 mg/mL, clear (warmed) |
| storage temp. | 2-8°C |
| SMILES string | O=C(C1=CC=CC=C1)NC2=NC3=C(N2CCCC4=CC=CC=C4)C=CC(C(OC)=O)=C3 |
| InChI | 1S/C25H23N3O3/c1-31-24(30)20-14-15-22-21(17-20)26-25(27-23(29)19-12-6-3-7-13-19)28(22)16-8-11-18-9-4-2-5-10-18/h2-7,9-10,12-15,17H,8,11,16H2,1H3,(H,26,27,29) |
| InChI key | UCGWYCMPZXDHNR-UHFFFAOYSA-N |
| 长度(mm) | |
| 宽度(mm) | |
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| 重量(kg) |
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