- 商品介绍
- 规格参数
- 包装参数
Biochem/physiol Actions
Potent Wnt/β-catenin signaling inhibitor that reduces airway basal stem cell (ABSC) proliferation and induces ciliated cell differentiation.
WIC1 is a potent Wnt/β-catenin signaling inhibitor (IC50 = 10 nM against 24h 5 μM CHIR-induced BEAS2B TCF/LEF reporter activity) that reduces airway basal stem cell (ABSC) proliferation (92% reduction of 4d 2 μM CHIR-induced hABSC proliferation by 1 μM WIC1) and induces ciliated cell differentiation (by 1.9-fold on d14 with 100 nM WIC1; mABSCs under air-liquid interface (ALI) condition) by suppressing β-catenin Y489 phosphorylation (complete inhibition of 24h 5 μM CHIR-induced pY489 in BEAS2B by 1 μM WIC1) and TP63 expression (80% reduction of 9d 1 μM CHIR-induced TP63 in mABSC by 1 μM WIC1; 40% reduction of 48h 5 μM CHIR-induced TP63 in BEAS2B by 1 μM WIC1).
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | yellow to brown |
| solubility | DMSO:methanol (1:1): 2 mg/mL, clear (Warmed) |
| storage temp. | -10 to -25°C |
| SMILES string | O=C1OC2=C(C=C1C(NC3=CC=C(N4CCN(CC4)CC)C=C3)=O)C=CC=C2 |
| InChI key | YQXKWSNLAVFZJL-UHFFFAOYSA-N |
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¥ 1082.93
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¥ 916.08
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¥ 625.35
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¥ 629.40
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