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PIK93，25MG，SML0546-25MG，Sigma

销售价： ¥ 5188.35 / 件

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订货号： 0BM6270

品牌型号： Sigma SML0546-25MG

货期：询货期

最小订货量： 1件

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商品介绍
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产品介绍 Product Description

Application

PIK93 has been used to examine if the accumulation of SNX27–retromer cargoes in FAM21 (family with sequence similarity 21) depleted cells is caused by an elevation of phosphatidylinositol 4-phosphate [PI(4)P] levels at the Golgi.

Biochem/physiol Actions

PIK93 is also known as N-(5-(4-Chloro-3-(((2-hydroxyethyl)amino)sulfonyl)phenyl)-4-methyl-2-thiazolyl)-acetamide. It inhibits poliovirus (PV) and coxsackievirus B3 (CVB3) viral RNA production and virus replication. PIK93 also prevents translation mediated by internal ribosome entry site (IRES).
PIK-93 inhibits of replication of enterovirus including polio and hepatitis C. PIK93 is a potent, selective, ATP competitive and reversible inhibitor of PI3Kγ and PI4KIIIβ (IC₅₀ = 16 nM and 19 nM, respectively). Also PIK93 moderately inhibits other members of the family including p110δ, PI 3-KC2β, hsVPS34, ATM, p110β and PI 4-KIIIα (IC₅₀ = 0.120, 0.140, 0.320, 0.490, 0.590 and 1.1 μM, respectively). PIK93 blocks ceramide transfer protein-mediated ceramide traffic between endoplasmic reticulum and Golgi.
PIK93 is an Inhibitor of enterviruses (including polio and hepatitis C) replication; PIK93 is a potent, selective, ATP competitive and reversible inhibitor of PI3Kγ and PI4KIIIβ.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

技术参数 Specifications

Quality Level	100
assay	≥98% (HPLC)
form	powder
storage condition	protect from light
color	white to beige
solubility	DMSO: 15 mg/mL, clear
storage temp.	2-8°C
SMILES string	[S](=O)(=O)(NCCO)c1c(ccc(c1)c2[s]c(nc2C)NC(=O)C)Cl
InChI	1S/C14H16ClN3O4S2/c1-8-13(23-14(17-8)18-9(2)20)10-3-4-11(15)12(7-10)24(21,22)16-5-6-19/h3-4,7,16,19H,5-6H2,1-2H3,(H,17,18,20)
InChI key	JFVNFXCESCXMBC-UHFFFAOYSA-N

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