- 商品介绍
- 规格参数
- 包装参数
Application
Ro 41-0960 has been used as an inhibitor of catechol-O-methyl-transferase in synaptosome membrane preparations and 3T3-L1 adipocytes. It has also been used as a catechol-O-methyl-transferase inhibitor to treat corpus striatum samples to test its effect on dopamine metabolism.
Biochem/physiol Actions
Ro 41-0960 is a specific and synthetic inhibitor of the enzyme catechol-O-methyl-transferase (COMT). It binds to the catalytic site and triggers the inhibition of the methylation property of COMT. Ro 41-0960 is effective on uterine leiomyoma lesions and uterine fibroids.
Features and Benefits
This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Disclaimer
Store tightly sealed at 4 °C, protected from exposure to light.
| form | solid |
| Quality Level | 100 |
| storage condition | protect from light |
| color | yellow |
| solubility | H2O: slightly soluble <0.7 mg/mL,45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.0 mg/mL,ethanol: soluble |
| storage temp. | 2-8°C |
| SMILES string | Oc1cc(cc(c1O)[N+]([O-])=O)C(=O)c2ccccc2F |
| InChI | 1S/C13H8FNO5/c14-9-4-2-1-3-8(9)12(17)7-5-10(15(19)20)13(18)11(16)6-7/h1-6,16,18H |
| InChI key | RQPAUNZYTYHKHA-UHFFFAOYSA-N |
| Gene Information | human ... COMT(1312) |
| 长度(mm) | |
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NALGENE 180透明塑料管，透明，柔软，多用，经济，内径 x 外径x壁厚，1/8 x 1/4 x 1/16，英寸，每箱数量50，50/箱，8000-0020，Thermofisher，赛默飞世尔
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