K11777，5MG，SML4046-5MG，Sigma

Biochem/physiol Actions

Orally bioavailable, non-toxic, covalent inactivator of cathepsin L and other cysteine proteases including Schistosoma mansoni SmCB1 and cruzain; reduces SARS-CoV-2 viral infectivity with no effect on PLpro and Mpro.

K11777 is an orally bioavailable, non-toxic, dipeptidyl vinyl-sulfone analog that acts as a potent, covalent inactivator of cathepsin L and other cysteine proteases. Reduces SARS-CoV-2 viral infectivity (EC50 = 74, <80 and 4 nM for Vero E6, A549/ACE2, and HeLa/ACE2 cells, respectively) with no effect on papain-like (PLpro) and 3CL cysteine proteases (Mpro), encoded by SARS-CoV-2 at ≤ 100 µM. K11777 inhibits Schistosoma mansoni cathepsin B1 (SmCB1) and cruzain. Displays broad-spectrum anti-parasitic activities.