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Biochem/physiol Actions
Biguanide-based mammalian respiratory complex I inhibitor that exhibits significantly higher potency than metformin and phenformin.
IM1761092 (IM1092) is a biguanide-based mammalian respiratory complex I inhibitor that reduces cellular oxygen consumption (IC50 = 3.6 μM post 6h treatment; HEPG2 C3A cells) and exhibits significantly higher potency than metformin and phenformin (by 10- to 2000-fold depending on the conditions) using bovine heart mitochondrial membrane preparations (IM1092/phenformin/metformin IC50 = 32 μM/3.8 mM/99 mM against active complex I, 4 μM/131 μM/33 mM against deactive complex I).
Disclaimer
Hygroscopic
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | white to beige |
| solubility | H2O: 2 mg/mL, clear |
| storage temp. | room temp |
| SMILES string | ClC1=CC(CCNC(NC(N)=N)=N)=CC=C1I.Cl |
| InChI key | NSBWTYOKPDFWFE-UHFFFAOYSA-N |
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