- 商品介绍
- 规格参数
- 包装参数
General description
Adenomatous polyposis coli protein (APC) is encoded by the gene mapped to human chromosome 5q. The encoded protein is composed of 2843 amino acids. APC exists as many transcripts and they are expressed in tissue specific manner.
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. (provided by RefSeq)
Immunogen
APC (NP_000029, 2744 a.a. ~ 2843 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
NPVPVSETNESSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDSKTDSTESSGTQSPKRHSGSYLVTSV
Biochem/physiol Actions
Adenomatous polyposis coli protein (APC) is a tumor suppressor gene. It plays an important role in cell division, adhesion and migration. Mutations in this gene are associated with familial adenomatous polyposis (FAP). APC is involved with Wnt pathway and inhibits the molecules which induce β-catenin expression, an agent participating in cellular transformation. It also regulates metaphase-anaphase transition, mitotic exit and G1 phase, thereby maintaining genomic stability and chromosome segregation.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in phosphate buffered saline, pH 7.4
Legal Information
GenBank is a registered trademark of United States Department of Health and Human Services
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | 3E2, monoclonal |
| form | buffered aqueous solution |
| species reactivity | human |
| technique(s) | immunofluorescence: suitable,indirect ELISA: suitable,proximity ligation assay: suitable,western blot: 1-5 μg/mL |
| isotype | IgG1κ |
| GenBank accession no. | NM_000038 |
| UniProt accession no. | P25054 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... APC(324) |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
-
询价
-
询价
-
¥ 1082.93
-
询价
-
¥ 580.62
-
询价
-
询价
-
¥ 1349.07
-
询价
-
¥ 1047.15
-
询价
-
¥ 520.54
-
¥ 1212.50
-
¥ 962.68
-
¥ 381.67
-
¥ 2396.11
-
¥ 64659.66
-
¥ 26022.64
-
¥ 108621.02
-
¥ 57595.03
微信小程序
7X24小时在线咨询