RO4929097，10MG，SML4098-10MG，Sigma

Biochem/physiol Actions

Orally active, potent and selective gamma-secretase inhibitor with anti-cancer efficacy in vitro and in vivo.

RO4929097 is an orally active, potent and selective gamma-secretase (γ-secretase) inhibitor (IC50 = 4 nM) that blocks Aβ1-40 production (IC50 = 14 nM in APP-overexpressing HEK293) and suppresses Notch signaling (IC50 = 5 nM by reporter assays) with >100-fold selectivity over 75 other enzymes, receptors and ion channels. RO4929097 reduces the size of MDA-MB-468 soft agar colonies in cultures (100-250 nM) and effectively suppresses A549 NSCLC xenografts-derived tumor growth in mice in vivo (3-60 mg/kg bid or qd p.o.).