cRIPGBM，5MG，SML2681-5MG，Sigma

Biochem/physiol Actions

Apoptosis inducer that binds receptor-interacting protein kinase 2 (RIPK2, RIP2) and promotes the proapoptotic RIPK2/caspase-1 complex formation.
cRIPGBM is an apoptosis inducer (GBM-1/-5/-39 EC₅₀ = 63/95/290 nM; human neural progenitor cells (NPCs)/astrocytes/lung fibroblasts EC₅₀ = 190/710/960 nM) that binds receptor-interacting protein kinase 2 (RIPK2, RIP2) and promotes the formation of a proapoptotic RIPK2/caspase-1 complex. Cell type-selective metabolic redox conversion of RIPGBM to cRIPGBM in glioblastoma multiforme (GBM) cancer stem cells (CSCs) form the basis of selective GBM CSCs apoptosis induction by RIPGBM over non-GBM cultures.