Anti-Potassium Channel KIR3.2 (GIRK2) antibody produced in rabbit，200UL，P8122-200UL，Sigma

General description

G protein-activated inward rectifier potassium channel 2 (GIRK2) is localized on the plasma membrane. It is expressed majorly in the brain and to some extent in the pancreas. The GIRK2 gene is mapped to human chromosome 21q22.13. Structurally, GIRK2 exists as a tetramer and comprises a transmembrane domain and a cytoplasmic domain.

Immunogen

GST fusion protein with sequence corresponding to residues 374-414 of mouse K_IR3.2 (GIRK2). Sequence homology is 40/41, 39/41, and 37/41 residues identical in rat, golden hamster, and human, respectively.

Application

Anti-Potassium Channel KIR3.2 (GIRK2) antibody produced in rabbit has been used in:

• immunoblotting
• immunofluorescence
• immunocytochemistry

Biochem/physiol Actions

Anti-Potassium Channel KIR3.2 (GIRK2) recognizesKIR3.2 (GIRK2).
G protein-activated inward rectifier potassium channel 2,(GIRK2) plays a key role in γ-aminobutyric acid-ergic (GABAergic), dopaminergic, cholinergic, and glutamatergic synapses. It also regulates neuronal excitability. GIRK2 through G protein-coupled receptor stimulation modulates neuronal circuit activity and heart rate in cardiac cells. Deletion of the GIRK2 gene in mice may lead to an anxiety-like phenotype and a depression-resistant behavior.

Physical form

Lyophilized powder from phosphate buffered saline containing 1% bovine serum albumin and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.