Anti-ARFGEF2 antibody produced in rabbit，100UL，SAB4301060-100UL，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

ADP ribosylation factor guanine nucleotide exchange factor 2 (ARFGEF2) possesses a Sec7 domain which is crucial for its activity. This protein is expressed in the brain and the gene encoding it is localized on human chromosome 20.

Immunogen

Synthetic peptide corresponding to a region derived from internal residues of human ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)

Biochem/physiol Actions

ADP ribosylation factor guanine nucleotide exchange factor 2 (ARFGEF2) activates ADP-ribosylation factors (ARFs) by exchanging guanosine diphosphate (GDP) with guanosine triphosphate (GTP). It aids in the release of type I tumor necrosis factor receptor (TNFR1) from human umbilical vein endothelial cells. Mutation in the ARFGEF2 gene has been linked to microcephaly and periventricular heterotopia.
The antibody detects endogenous levels of total ARFGEF2 protein.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in pH7.3 PBS, 0.05% NaN₃, 50% Glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

技术参数 Specifications

biological source	rabbit
Quality Level	100
conjugate	unconjugated
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
form	buffered aqueous solution
mol wt	202 kDa
species reactivity	mouse, human
concentration	3.4 mg/mL
technique(s)	immunohistochemistry: 1:50- 1:200,western blot: 1:200-1:1000 (Cell Lysate)
isotype	IgG
accession no.	NP_006411.2
UniProt accession no.	Q9Y6D5
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... ARFGEF2(10564)

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