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Biochem/physiol Actions
SMIP004-7 is a cell penetrant, potent and selective ubiquinone uncompetitive inhibitor of mitochondrial Complex I (NADH:ubiquinone oxidoreductase). SMIP004-7 selectively binds to a distinct N-terminal region of Complex I catalytic subunit NDUFS2, which leads to rapid disassembly of Complex I. SMIP004-7 potently inhibits growth of triple-negative breast cancer xenografts in mice.
cell penetrant, potent and selective ubiquinone uncompetitive inhibitor of mitochondrial Complex I
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | (Oil or liquid) |
| color | colorless to brown |
| storage temp. | -10 to -25°C |
| SMILES string | Nc1c(cc(cc1)CCCC)C |
| InChI key | JTXOXRXZCAMPHL-UHFFFAOYSA-N |
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¥ 2019.57
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