Monoclonal Anti-CD79b PE produced in mouse，100YL4，SAB4702020-100TST，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

CD79b (Ig beta, B29) forms disulfide-linked heterodimer with CD79a (Ig alpha, MB1). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.

Immunogen

Fraction of Ig-associated molecules isolated from Ramos B cells

Biochem/physiol Actions

The mouse monoclonal antibody CB3-1 recognizes an extracellular epitope of CD79b (CD79 beta, Ig beta), an approximately 38 kDa component of B cell receptor (BCR) complex.

Physical form

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preparation Note

Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Other Notes

The antibody solution should be gently mixed before use.

技术参数 Specifications

conjugate	phycoerythrin (R-PE) conjugate
Quality Level	100
antibody product type	primary antibodies
clone	CB3-1, monoclonal
form	buffered aqueous solution
species reactivity	human
technique(s)	flow cytometry: suitable
isotype	IgG1κ
UniProt accession no.	P40259
storage temp.	2-8°C
target post-translational modification	unmodified
Gene Information	human ... CD79B(974)

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