- 商品介绍
- 规格参数
- 包装参数
General description
Extracellular signal-regulated kinase 1 (ERK1) belongs to mitogen-activated protein kinases (MAPK)/ERK family of intermediate proteins in the signaling pathways. This gene contains nine exons and eight introns, and spans 9kb. It is a constitutively expressed protein, the activity of which is altered by the phosphorylation state. It has a higher expression level in nervous tissues. It contains 11 kinase subdomains, common between humans and mice. It has a molecular weight of 44kDa.
Biochem/physiol Actions
ERK1 (MAPK3) participates in cellular signaling cascades that are activated in response to numerous growth factors and cytokines. Disruption of MAP kinase signaling functionality is associated with disease states including inflammation, cancer and neurodegenerative disease.
Extracellular signal-regulated kinase 1 (ERK1) act as intermediate in multiple signaling cascades, and is acted upon by MEK protein. MEK are essential for Golgi fragmentation during mitosis, and this is achieved by its action upon an alternatively spliced isoform of ERK1, called ERK1c. ERK1/2 signaling plays a key role in cellular response to topoisomerase II poisoning, by activating G2/M checkpoint, and thus, prevents poison-induced cell death. In melanocytes, pleiotrophin suppresses pigmentation or melanogenesis, by degradation of MITF, through the activation of ERK1/2 signaling.
Physical form
Supplied in 25 mM MOPS, pH 7.5, with 300 mM NaCl, 0.25 mM DTT, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
| recombinant | expressed in baculovirus infected Sf9 cells |
| Quality Level | 200 |
| product line | PRECISIO® Kinase |
| assay | ≥70% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| specific activity | 329-445 nmol/min·mg |
| mol wt | ~44 kDa |
| UniProt accession no. | P27361 |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... MAPK3(5595) |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
-
¥ 1011.55
-
¥ 1665.68
-
询价
-
询价
-
询价
-
询价
-
询价
-
¥ 1958.88
-
¥ 4110.85
-
¥ 1761.75
-
¥ 3593.05
-
¥ 2024.55
-
NNALGENE 180透明塑料管，透明，柔软，多用，经济，内径 x 外径x壁厚，1/4 x 1/2 x 1/8，英寸，每箱数量50，50/箱，8000-0080，Thermofisher，赛默飞世尔询价
-
询价
-
询价
-
¥ 8072.66
-
¥ 55311.07
-
询价
-
¥ 402833.12
-
¥ 390328.90
微信小程序
7X24小时在线咨询