- 商品介绍
- 规格参数
- 包装参数
General description
The Phospho-Stat1 (pSer727) ELISA (Enzyme-Linked Immunosorbent Assay) kit is a very rapid, convenient and sensitive assay kit that can monitor the activation or function of important biological pathways in cell lysates.
Immunogen
Stat1 (pTyr727) synthetic phosphopeptide, Recombinant Human STAT1
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Biochem/physiol Actions
Signal transducer and activator of transcription 1 (STAT1) undergoes phosphorylation on serine-727. This Phospho-Stat1 regulates pro- and anti-apoptotic genes following several stress-induced responses. STAT-1 interacts with p53 and promotes p53-mediated transcriptional gene activity and apoptosis. STAT-1 is an essential factor of stress-induced and DNA damage-induced checkpoint pathways and thus, acts as a tumour suppressor. STAT-1 functions as a pro-apoptotic factor in cardiac myocytes, brain or liver exposed to ischaemia–reperfusion injury. Thus, inhibition of STAT-1-activated pathway by epigallocatechin-3-gallate (EGCG), can be considered as a potential therapeutic method against ischaemic tissue injury. Repression of STAT-1 expression by human papillomavirus (HPV) oncoproteins E6 and E7 at transcription level is essential for genome amplification and maintenance of episomes, which is suggested to have a crucial role in viral pathogenesis.
| species reactivity | mouse, human |
| technique(s) | ELISA: suitable,capture ELISA: suitable |
| shipped in | wet ice |
| storage temp. | −20°C |
| Gene Information | human ... STAT1(6772) mouse ... STAT1(20846) |
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¥ 6894.69
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¥ 5725.45
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¥ 3290.05
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¥ 2842.54
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¥ 3852.13
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¥ 5061.38
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¥ 5804.96
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¥ 5990.26
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¥ 165230.53
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¥ 30616.15
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