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Ophiobolin A，100UG，SML1478-100UG，Sigma

销售价： ¥ 941.86 / 件

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订货号： 0BL1439

品牌型号： Sigma SML1478-100UG

货期：询货期

最小订货量： 1件

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商品介绍
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包装参数

产品介绍 Product Description

Biochem/physiol Actions

Ophiobolin A is a fungal metabolite, toxic to many crops and found to have antimicrobial and anticancer activity. Ophiobolin A is a calmodulin antagonist and inhibitor of big conductance Ca2+-activated K+ channel (BKCa) activity. Its anticancer activity may involve inhibition of multiple oncogenic signaling pathways including PI3K/mTOR, Ras/Raf/ERK and CDK/RB. One study suggested the possibility of pyrrolylation of lysine residues on its intracellular target protein(s) as a mechanism of action on various targets.
Ophiobolin A is a fungal metabolite; calmodulin antagonist with anticancer activity.

Other Notes

Light and air sensitive.

技术参数 Specifications

biological source	(from Biopolaris leersia fungal metabolite)
Quality Level	100
assay	≥95% (HPLC)
form	powder
storage condition	protect from light
color	white to beige
storage temp.	−20°C
SMILES string	[H]C(/C1=C/C[C@]([C@]2(O[C@@H](C=C(C)C)C[C@@H]2C)CC3)([H])[C@@]3(C)C[C@@]([C@](C)(O)C4)([H])[C@]1([H])C4=O)=O
InChI	1S/C25H36O4/c1-15(2)10-18-11-16(3)25(29-18)9-8-23(4)12-19-22(20(27)13-24(19,5)28)17(14-26)6-7-21(23)25/h6,10,14,16,18-19,21-22,28H,7-9,11-13H2,1-5H3/b17-6-/t16-,18-,19-,21+,22+,23+,24+,25-/m0/s1
InChI key	MWYYLZRWWNBROW-BDZRSQQBSA-N

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