- 商品介绍
- 规格参数
- 包装参数
General description
Protein kinase C α (PRKCA) is encoded by the gene mapped to human chromosome 17q24.2. The encoded protein is a member of the serine/threonine-specific protein kinase family.
Immunogen
Peptide sequence around phosphorylation site of tyrosine 658(F-S-Y(p)-V-N) derived from Human PKC α.
Biochem/physiol Actions
Protein kinase C α (PRKCA) is a serine-threonine kinase. It is associated with tumorigenesis, invasion, apoptosis, differentiation, angiogenesis and metastasis. Downregulation of PKCA inhibits the invasion of urinary bladder, colon, renal cell, breast carcinomas, multiple myeloma, glioma and endometrial cancer cells. In endothelial cells, PRKCA-mediated phosphorylation of TRPC1 (transient receptor potential cation channel subfamily C member 1) regulates store operated Ca2+ entry.
The antibody detects endogenous levels of PKC α only when phosphorylated at tyrosine 658.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | 80 kDa |
| species reactivity | human |
| concentration | 1.0 mg/mL |
| technique(s) | western blot: 1:500-1:1000 (Cell Lysate) |
| isotype | IgG |
| accession no. | NP_002728.1. |
| UniProt accession no. | P17252 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pTyr657) |
| Gene Information | human ... PRKCA(5578) |
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