Monoclonal Anti-FGF8 antibody produced in mouse，100UG，SAB1409000-100UG，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. (provided by RefSeq)

Immunogen

FGF8 (NP_149354, 65 a.a. ~ 133 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
SRRLIRTYQLYSRTSGKHVQVLANKRINAMAEDGDPFAKLIVETDTFGSR VRVRGAETGLYICMNKKGK

Biochem/physiol Actions

Fibroblast growth factor-8 (FGF-8) stimulates the proliferation and activation of cells that express the FGF receptors. It has a role in embryogenesis. FGF8b, an isoform of FGF-8, is expressed in prostate cancer.

Physical form

Solution in phosphate buffered saline, pH 7.4

技术参数 Specifications

biological source	mouse
Quality Level	100
conjugate	unconjugated
antibody form	purified immunoglobulin
antibody product type	primary antibodies
clone	3H2, monoclonal
form	buffered aqueous solution
mol wt	antigen 33.22 kDa
species reactivity	human
technique(s)	indirect ELISA: suitable,western blot: 1-5 μg/mL
isotype	IgG2aκ
NCBI accession no.	NM_033164
UniProt accession no.	P55075
shipped in	dry ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... FGF8(2253)

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