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General description
The human BTC gene (Gene ID 685) encodes the 178 aa preprobetacellulin (UniProt P35070) protein. Post-translatioinal removal of the signal peptide (aa 1-31) produces probetacellulin (aa 32-178), which further matures into the 80 aa betacellulin (aa 32-111) following propeptide (aa 112-178) removal. Betacellulin is an EGF family growth factor with a higher affinity and specificity for ErbB1/EGFR and ErbB4. Betacellulin plays an important role in the development of the acute exacerbations of chronic obstructive pulmonary disease. Betacellulin is also reported to induce CXCL8 (IL-8) production from human lung cancer cells through EGFR–PI3K–Akt–ERK pathway activation, resulting in the recruitment of inflammatory cells in the cancer tissue and creating an inflammatory tumor microenvironment.
~20 kDa observed. Preprobetacellulin (19.7 kDa calculated); Probetacellulin (16.6 kDa calculated); Betacellulin (9.0 kDa calculated). Due to posttranslational glycosylation, target band(s) will migrate with a higher apparent M.W. than caluclated.
Immunogen
Epitope: Mature betacellulin
GST-tagged human recombinant full-length mature betacellulin.
Application
Research Sub Category
Signaling Neuroscience
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Betacellulin in human pancreas tissue.
Research Category
Signaling
This Anti-Betacellulin Antibody, clone 6G10.1 is validated for use in Western Blotting, Immunohistochemistry for the detection of Betacellulin .
Biochem/physiol Actions
Clone 6G10.1 is expected to detect prepro-, pro-, and mature betacellulin.
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in human pancreas tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Betacellulin in 10 µg of human pancreas tissue lysate.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | 6G10.1, monoclonal |
| species reactivity | human |
| technique(s) | immunohistochemistry: suitable,western blot: suitable |
| isotype | IgG1κ |
| NCBI accession no. | NP_001720 |
| UniProt accession no. | P35070 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... BTC(685) |
| 长度(mm) | |
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