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General description
A member of the SNF2 family of chromatin remodeling proteins, Lymphoid-specific helicase (HELLS, also known as Lsh) assumes various roles in normal development, survival, de novo or maintenance DNA methylation, gene silencing, and heterochromatin formation and organization. It is shown to serve as cancer progression marker in conjunction with CEP55 and FOXM1 for the detection of head and neck squamous cell carcinoma (HNSCC). It is also reported that expression of Lsh is crucial for meiotic progression in mouse spermatocytes. Lsh is shown to directly associate with the 5′ DMR of the Cdkn1c promoter, and thereby regulate its gene expression. Additionally, Lsh is reported as a regulator of repressive chromatin at retrotransposons, and is demonstrated to mediate the silencing of stem cell-specific genes such as Oct4.
~97 kDa observed
Immunogen
GST-tagged recombinant protein corresponding to human Lymphoid-specific helicase (SMARCA6).
Application
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Lymphoid-specific helicase (SMARCA6) in human placenta tissue.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Signaling Neuroscience
This Anti-Lymphoid-specific helicase (SMARCA6) Antibody, clone 2G7.1 is validated for use in western blotting & IHC for the detection of Lymphoid-specific helicase (SMARCA6).
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in human thymus tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Lymphoid-specific helicase (SMARCA6) in 10 µg of human thymus tissue lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified antibody |
| antibody product type | primary antibodies |
| clone | 2G7.1, monoclonal |
| species reactivity | human |
| technique(s) | immunohistochemistry: suitable,western blot: suitable |
| isotype | IgG1κ |
| NCBI accession no. | NP_060533 |
| UniProt accession no. | Q9NRZ9 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... HELLS(3070) |
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