Anti-ERLIN1 antibody produced in rabbit，100UL，HPA011252-100UL，Sigma

General description

ERLIN1 (ER lipid raft associated 1) is a member of the prohibitin protein family, and contains the ~160 amino acid long prohibitin-homology domain (PHB). It has a molecular weight of ~40kDa. It exists in association with lipid rafts, and is found in the ER (endoplasmic reticulum). ERLIN1 mRNA is expressed in a wide range of human tissues. This protein contains a transmembrane N-terminal, which is responsible for targeting this protein to the ER, and a C-terminal containing the SPFH (Stomatin, Prohibitin, Flotillin, and HflC/HflK) domain, projecting into the ER lumen. ERLIN1 forms a hetero-oligomeric complex with ERLIN2, with which it shares high sequence homology.

Immunogen

Erlin-1 recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Biochem/physiol Actions

ERLIN1 (ER lipid raft associated 1) is differentially expressed in activated and non-activated dendritic cells (DCs), and might play a role in the activation of DCs. ERLIN1/ERLIN2 complex is involved in the endoplasmic reticulum (ER) associated degradation (ERAD) of inositol 1,4,5-trisphosphate (IP₃) receptor, post IP₃-receptor activation. Variants in the ERLIN1-CHUK-CWF19L1 gene cluster are associated with simple steatosis and hepatic steatosis with inflammation. Thus, this cluster might influence the susceptibility to non-alcoholic fatty liver disease (NAFLD). ERLIN1 regulates and inhibits sterol regulatory element binding proteins (SREBPs) during cholesterol sufficiency, and therefore, contributes to cellular cholesterol homeostasis.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Other Notes

Corresponding Antigen APREST71702

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.