抗-磷酸化-JAK2 (pTyr¹⁰⁰⁷) 兔抗，100UG，SAB4300124-100UG，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

Janus kinase 2(JAK2) mapped on human chromosome 9p24, encodes a tyrosine kinase. The encoded protein is a member of the Jak family of protein. JAK2 is ubiquitously expressed. This protein contains a catalytic domain and protein–protein interaction domain.
Plays a role in leptin signaling and control of body weight.

Immunogen

Peptide sequence around phosphorylation site of tyrosine 1007 (K-E-Y(p)-Y-K), according to the protein JAK2.

Biochem/physiol Actions

Janus kinase 2(JAK2) plays an important role in the activities of cytokines receptors. Overexpression of JAK2 results in neuroblastoma. JAK2 mutations promote primary resistance to PD-1 (anti-programmed death protein 1) blockade therapy. In addition, mutations in the gene has also been observed in polycythaemia vera patients.

Features and Benefits

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Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

技术参数 Specifications

biological source	rabbit
Quality Segment	100
conjugate	unconjugated
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
form	buffered aqueous solution
mol wt	~125 kDa
species reactivity	mouse, rat, human
concentration	1 mg/mL
technique(s)	immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100,western blot: 1:500-1:1000
isotype	IgG
immunogen sequence	(K-E-YP-Y-K)
NCBI accession no.	NP_004963.1
UniProt accession no.	O60674
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	phosphorylation (pTyr1007)
Gene Information	human ... JAK2(3717)

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