- 商品介绍
- 规格参数
- 包装参数
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规格 |
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| Accession Number: | PIK3CA E455K: NP_006209.2, PIK3R1(p110a) : NP_852664.1 |
| Protein Form: | Full Length, Recombinant, Active, Mutant |
| Shipping Condition: | Dry Ice |
| Molecular Weight: | 125.4/84.7 kDa |
| Validated Application: | Kinase Assay |
| Expression System: | Insect |
| KinaseFamily: | PI3 Kinase |
| Protein Length: | Full Length |
| Protein Tag: | His Tag |
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储存 |
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| Storage Buffer: 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol. |
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描述 |
This PIK3CA E545K/PIK3R1 (p110 alpha E545K/p85 alpha) recombinant human protein (full length) was expressed in insect cells. PIK3CA (E545K)/PIK3R1 lipid kinase (p110 alpha E545K/p85 alpha) consists of a 110 kDa catalytic subunit and an 85 kDa regulatory subunit. A number of isoforms of the 110 kDa catalytic subunit and the 85 kDa regulatory subunit exist in cells. The PIK3CA catalytic subunit is frequently mutated or amplified in a variety of cancers including ovarian and colon and this protein is one of the PI3K mutants. PIK3CA gene copy number is increased in over 30% of ovarian cancers and this leads to increased PI3-kinase activity. Furthermore, the activity of PIK3CA is essential for vascular development and inactivation of PIK3Ca leads to severe defects in angiogenic sprouting and vascular remodeling. PIK3CA E545K/PIK3R1 (p110 alpha E545K/p85 alpha) recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.
• Validated for use with the Adapta™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service
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| 重量(kg) |
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询价
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询价
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¥ 632.25
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¥ 587.04
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¥ 543.43
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¥ 1490.43
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¥ 177.50
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¥ 463.80
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¥ 632.10
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询价
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询价
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询价
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¥ 2369.85
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¥ 1084.92
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询价
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¥ 3362.96
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¥ 593.88
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¥ 3055.44
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¥ 1509.78
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