规格
|
Crosslinker Type:
|
Heterobifunctional |
Labeling Method:
|
Chemical Labeling |
Product Line:
|
Pierce™ |
Reactive Moiety:
|
Maleimide, NHS Ester |
Spacer:
|
Long |
Solubility:
|
DMSO (Dimethylsulfoxide), DMF (Dimethylformamide) |
储存
|
Upon receipt store desiccated at 4°C. Product is shipped at ambient temperature. |
Thermo Scientific Pierce SMPH is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a long spacer arm (14.2 angstroms).
Features of SMPH:
• Reactive groups: NHS ester and maleimide
• Reactive towards: amino and sulfhydryl groups
• Slightly longer and more soluble than SMPB
• NHS ester reacts with primary amines at pH 7-9, forming a stable amide bond
• Maleimide reacts with -SH groups at pH 6.5-7.5, forming a stable thioether bond
• Non-cleavable
• Water-insoluble (dissolve first in DMF or DMSO)
Product References:
Crosslinker Application Guide -- search for recent literature references for this product
Related Products
SMPH (Succinimidyl 6-((beta-maleimidopropionamido)hexanoate))