Anti-F4/80-PE-Vio615, mouse，130-123-913，美天旎

Clone REA126 recognizes F4/80, a member of epidermal growth factor (EGF)-transmembrane 7 (TM7) family. F4/80 is considered as one of the most specific cell-surface markers for murine macrophages. F4/80 is a seven-span transmembrane molecule with a large extracellular, multiple EGF module–containing domain. Constitutive and high expression of F4/80 is found on most resident tissue macrophages, including the spleen, microglia in the brain, Kupffer's cells in the liver, and Langerhans cells in the skin. In addition, the expression of F4/80 can also be regulated depending on the physiological status of the cell. F4/80 molecule is required for the differentiation of antigen-specific CD8⁺ Tregs and is involved in inducing peripheral immune tolerance. No specific ligand for F4/80 has been reported so far.

Additional information: Clone REA126 displays negligible binding to Fc receptors.

ADGRE1, DD7A5-7, EGF-TM7, EMR1, Gpf480, Ly71, TM7LN3

Technical specifications