Anti-Oct3/4-APC, human and mouse，130-123-257，美天旎

Clone REA622 recognizes the human and mouse octamer-binding transcription factor 3/4 (Oct3/4). Oct3/4 is a homeodomain transcription factor belonging to the POU transcription factor family and is also known as POU domain class 5 transcription factor 1 (POU5F1). Oct3/4 is critical for the maintenance of totipotency in primate blastomeres and for pluripotency of the inner cell mass of developing mammalian embryos. This critical role of Oct3/4 is maintained in embryonic stem cells, the developing germline, and germline tumors, such as seminomas and embryonic teratocarcinomas. When inducing pluripotency in differentiated cells, Oct3/4 appears to be an essential but not the only required transcription factor. Oct3/4 acts as a transcriptional activator of genes involved in maintenance of undifferentiated state and as a repressor of differentiation-specific genes.

Additional information: Clone REA622 displays negligible binding to Fc receptors.

Oct3/4A, Oct-3A, Oct-4, OTF-3, OTF-4, POU5F1, NF-A3, MGC22487

Technical specifications