Anti-TNF-α-APC, mouse，130-123-277，美天旎

Clone REA636 recognizes the mouse tumor necrosis factor α (TNF-α) antigen, a 17 kDa cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF-α is produced by cells that are involved in inflammatory immune responses. It is secreted by activated CD4⁺ T cells, monocytes, macrophages, NK cells, and neutrophils. TNF-α binding to surface receptors elicits a wide array of biologic activities, including cytolysis and cytostasis of many tumor cell lines in vitro, hemorraghic necrosis of tumors in vivo, increased fibroblast proliferation, and enhanced chemotaxis and phagocytosis in neutrophils. Furthermore it causes fever by direct action or by stimulation of interleukin-1 secretion.

Additional information: Clone REA636 displays negligible binding to Fc receptors.

TNFa, TNFalpha, TNF-alpha, Cachectin, Tnfsf1a, TNFSF2

Technical specifications