- 商品介绍
- 规格参数
- 包装参数
Clone REA661 recognizes the human CD80 antigen, also known as B7-1. CD80 is a 262 amino acid long 60 kDa molecule and a member of the immunoglobulin superfamily. Together with CD86 (B7-2) it belongs to the B7 family of costimulatory molecules. CD80 is expressed on activated B cells, dendritic cells, and monocytes/ macrophages. The interaction of CD80 with its ligands CD28 and CD152 (CTLA-4) plays a critical role in induction and regulation of immune responses. Binding of CD80 to CD28, which is constitutively expressed on T cells, provides a costimulatory signal and induces T cell proliferation and cytokine production. In contrast, binding to CTLA-4 strongly inhibits proliferation and IL-2 secretion by T cells.
Additional information: Clone REA661 displays negligible binding to Fc receptors.
B7, B7-1, BB1
Technical specifications
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