CD16 Antibody, anti-human, Vio® Bright V600, REAfinity™,130-131-159,美天旎

销售价: ¥ 6809.38 / 件
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订货号 4UH7803
品牌型号 美天旎 130-131-159
货期 询货期
最小订货量 1件
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产品介绍 Product Description

Clone REA423 recognizes the human CD16 antigen, a single-pass type I membrane protein which is also known as low affinity immunoglobulin gamma Fc region receptor III (FcRIII). CD16 is a 50–80 kDa glycoprotein that is expressed in two different isoforms. The transmembrane form is found on human NK cells, macrophages, and mast cells, while the glycosylphosphatidylinositol (GPI)-linked form is present on neutrophils. The human CD16 antigen is a low-affinity receptor for aggregated IgG. The transmembrane form plays a role in signal transduction, NK cell activation, and antibody-dependent cellular cytotoxicity. Clone REA423 recognizes both the extracellular domain of the transmembrane form as well as the GPI-linked form of the human CD16 antigen. CD16 is expressed on the majority of rhesus monkey NK cells and on a subset of monocytes but not on granulocytes.

Additional information: Clone REA423 displays negligible binding to Fc receptors.


Alternative names

FCGR3A, FCGR3B, FcR-10, IGFR3, IMD20, FcRIII


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